Pharmaceutical and Molecular Biotechnology Research Centre

Research output

Research output per year 2000 2011 2012 2013 2014 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 232 Article
• 23 Review article
• 17 Poster
• 12 Chapter
• 49 More
  • 12 Patent
  • 7 Conference contribution
  • 7 Presentation
  • 7 Doctoral Thesis
  • 4 Commissioned report
  • 3 Paper
  • 3 Other contribution
  • 2 Editorial
  • 1 Book
  • 1 Comment/debate
  • 1 Short survey
  • 1 Digital or Visual Products

Research output per year

Research output per year

Search results

• 2017

  MiRNA biogenesis and regulation of diseases: An overview

  Vishnoi, A. & Rani, S., 2017, Methods in Molecular Biology. Humana Press Inc., p. 1-10 10 p. (Methods in Molecular Biology; vol. 1509).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • MicroRNA 100%
  • Biogenesis 100%
  • RNA 20%
  • Biological Phenomena and Functions Concerning the Entire Organism 20%
  • Drug Response 20%
  586 Citations (Scopus)

• Non-invasive strategies for targeting the posterior segment of eye

  Madni, A., Rahem, M. A., Tahir, N., Sarfraz, M., Jabar, A., Rehman, M., Kashif, P. M., Badshah, S. F., Khan, K. U. & Santos, H. A., 2017, In: International Journal of Pharmaceutics.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Preparation of Cellulose Nanocrystal-Reinforced Poly(lactic acid) Nanocomposites through Noncovalent Modification with PLLA-Based Surfactants

  Mariano, M., Pilate, F., Oliveira, F. B. D., Khelifa, F., Dubois, P., Raquez, J.-M. & Dufresne, A., Jun 2017, In: ACS Omega.

  Research output: Contribution to journal › Article › peer-review
  68 Citations (Scopus)

• Real-time PCR detection of aldoxime dehydratase genes in nitrile-degrading microorganisms

  Dooley-Cullinane, T. M., O’Reilly, C. & Coffey, L., 01 Feb 2017, In: Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 110, 2, p. 271-279 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitrile 100%
  • Hydrolyase 100%
  • Aldoxime 100%
  • Microorganism 100%
  • Dehydratase 100%
  5 Citations (Scopus)

• Recent developments on nanocellulose reinforced polymer nanocomposites: A review

  Kargarzadeh, H., Mariano, M., Huang, J., Lin, N., Ahmad, I., Dufresne, A. & Thomas, S., 2017, In: Polymer.

  Research output: Contribution to journal › Article › peer-review
  527 Citations (Scopus)

• Thiolated polymers as mucoadhesive drug delivery systems

  Duggan, S., Cummins, W., O' Donovan, O., Hughes, H. & Owens, E., 30 Mar 2017, In: European Journal of Pharmaceutical Sciences. 100, p. 64-78 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Controlled Drug Release 100%
  • Controlled Release 100%
  • Drug Delivery System 100%
  • Drug Delivery Device 100%
  • Side Effect 100%
  79 Citations (Scopus)
• 2016

  Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach

  Nolan, J. A., Kinsella, M., Hill, C., Joyce, S. A. & Gahan, C. G. M., 01 Jul 2016, In: Current Microbiology. 73, 1, p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Infectious Agent 100%
  • Supernatant 100%
  • Bacterial Cell 100%
  • Staphylococcus Aureus 100%
  • Listeria monocytogenes 100%
  5 Citations (Scopus)

• An Evolutionary Switch in ND2 enables Src kinase regulation of NMDA receptors

  Scanlon, D., Bah, A., Krzeminski, M., Zhang, W., Leduc-Pessah, H. L., Dong, Y. N., Forman-Kay, J. D. & Salter, M. W., Jul 2016.

  Research output: Contribution to conference › Poster

• An Evolutionary Switch in ND2 enables Src kinase regulation of NMDA receptors

  Scanlon, D., Bah, A., Krzeminski, M., Zhang, W., Leduc-Pessah, H. L., Dong, Y. N., Forman-Kay, J. D. & Salter, M. W., May 2016.

  Research output: Contribution to conference › Poster

• An investigation into the crystallization tendency/kinetics of amorphous active pharmaceutical ingredients: A case study with dipyridamole and cinnarizine

  Baghel, S., Cathcart, H., Limerick, U. & O'Reilly, N., 01 Jul 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 104, p. 59-71 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystallization Kinetics 100%
  • Cinnarizine 100%
  • Dipyridamole 100%
  • Crystallization 100%
  • Glass Transition Temperature 50%
  38 Citations (Scopus)

• A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal pathogens

  Davitt, C. J. H., McNeela, E. A., Longet, S., Tobias, J., Aversa, V., McEntee, C. P., Rosa, M., Coulter, I. S., Holmgren, J. & Lavelle, E. C., 10 Jul 2016, In: Journal of Controlled Release. 233, p. 162-173 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Adjuvant 100%
  • Infectious Agent 100%
  • Enterotoxigenic Escherichia Coli 100%
  • Stomach pH 100%
  • Immunoglobulin A 50%
  27 Citations (Scopus)

• Capitalizing on SME Green Innovation Capabilities: Lessons from Irish-Welsh Collaborative Innovation Learning Network

  Harrington, D., Walsh, M., Owens, E., Joyner, D. J., McDonald, M., Griffiths, G., Doyle, E. & Lynch, P., 2016

  Research output: Other contribution › peer-review

• Cellulose nanocrystal reinforced oxidized natural rubber nanocomposites

  Mariano, M., 2016, TAPPI International Conference on Nanotechnology for Renewable Materials 2016.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Cellulose nanocrystal reinforced oxidized natural rubber nanocomposites

  Mariano, M., 2016, In: Carbohydrate Polymer.

  Research output: Contribution to journal › Article › peer-review
  130 Citations (Scopus)

• Comparison of the mucoadhesive properties of thiolated polyacrylic acid to thiolated polyallylamine

  Duggan, S., O'Donovan, O., Owens, E., Duggan, E., Hughes, H. & Cummins, W., 10 Feb 2016, In: International Journal of Pharmaceutics. 498, 1-2, p. 245-253 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Polyacrylic Acid 100%
  • Synthetic Polymer 100%
  • Pig 20%
  • Drug Release 20%
  • Drug Delivery Device 20%
  12 Citations (Scopus)

• Comprehensive morphological and structural investigation of cellulose i and II nanocrystals prepared by sulphuric acid hydrolysis

  Flauzino Neto, W. P., Putaux, J.-L., Mariano, M., Ogawa, Y., Otaguro, H., Pasquini, D. & Dufresne, A., 2016, In: RSC Advances.

  Research output: Contribution to journal › Article › peer-review
  94 Citations (Scopus)

• Dispersive liquid-liquid microextraction in the analysis of milk and dairy products: A review

  Quigley, A., Cummins, W. & Connolly, D., 2016, In: Journal of Chemistry. 2016, 4040165.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Dairy Product 100%
  • Microextraction 100%
  • Liquid Liquid Microextraction 100%
  • Yogurt 25%
  • Infant Formula 25%
  68 Citations (Scopus)

• Identification and characterization of in vivo metabolites of asulacrine using advanced mass spectrophotometry technique in combination with improved data mining strategy

  Afzal, A., Zhong, Y., Sarfraz, M., Peng, Y., Sheng, L., Wu, Z., Sun, J. & Wang, G., 2016, In: Journal of Chromatography A.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Impact of cellulose nanocrystal aspect ratio on crystallization and reinforcement of poly(butylene adipate-co-terephthalate)

  Mariano, M., Chirat, C., Kissi, N. E. & Dufresne, A., Jul 2016, In: J. Polym. Sci. Part B: Polym. Phys..

  Research output: Contribution to journal › Article › peer-review
  61 Citations (Scopus)

• Influence of a low-carbohydrate diet on endothelial microvesicles in overweight women

  Wekesa, A. L., Doyle, L. M., Fitzmaurice, D., O'Donovan, O., Phelan, J. P., Ross, M. D., Cross, K. S. & Harrison, M., 01 May 2016, In: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 41, 5, p. 522-527 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Low Carbohydrate Diet 100%
  • Obesity 100%
  • Biological Marker 100%
  • Microvesicles 100%
  • Body Mass 60%
  12 Citations (Scopus)

• Integrated scientific data bases review on asulacrine and associated toxicity

  Afzal, A., Sarfraz, M., Wu, Z., Wang, G. & Sun, J., 2016, In: Critical Reviews in Oncology/Hematology.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Mechanical properties of natural rubber nanocomposites reinforced with high aspect ratio cellulose nanocrystals isolated from soy hulls

  Neto, W. P. F., Mariano, M., Silva, I. S. V. D., Silvério, H. A., Putaux, J.-L., Otaguro, H., Pasquini, D. & Dufresne, A., Nov 2016, In: Carbohydrate Polymers.

  Research output: Contribution to journal › Article › peer-review
  169 Citations (Scopus)

• Mesenchymal stromal cells (MSCs) and colorectal cancer - A troublesome twosome for the anti-tumour immune response?

  O'Malley, G., Heijltjes, M., Houston, A. M., Rani, S., Ritter, T., Egan, L. J. & Ryan, A. E., 2016, In: Oncotarget. 7, 37, p. 60752-60774 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neoplasm 100%
  • Immune Response 100%
  • Mesenchymal Stem Cell 100%
  • Colorectal Carcinoma 100%
  • Stromal Cell 100%
  49 Citations (Scopus)

• Performance enhancement of PEBAX using supercritical fluid extrusion for biomedical applications

  Karode, N., Fitzhenry, L., Poudel, A., Walsh, P., Matthews, S. & Coffey, A., 2016, ANTEC 2016 - Proceedings of the Annual Technical Conference and Exhibition of the Society of Plastics Engineers. Society of Plastics Engineers, p. 1377-1382 6 p. (Annual Technical Conference - ANTEC, Conference Proceedings).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Biomedical Application 100%
  • Pebax 100%
  • Supercritical Fluid 100%
  • Carbon Dioxide 100%
  • Mechanical Performance 33%
  5 Citations (Scopus)

• Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs

  Baghel, S., Cathcart, H. & O'Reilly, N., 01 Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2527-2544 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Crystallization 100%
  • Amorphous Solid Dispersion 100%
  727 Citations (Scopus)

• Polystyrene-co-divinylbenzene polyHIPE monoliths in 1.0 mm column formats for liquid chromatography

  Choudhury, S., Fitzhenry, L., White, B. & Connolly, D., 18 Mar 2016, In: Materials. 9, 3, 212.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Styrofoam 100%
  • Divinylbenzene 100%
  • Reverse Phase High Performance Liquid Chromatography 33%
  • Methacrylate 33%
  • Alkylbenzene 33%
  11 Citations (Scopus)

• Proteomic characterisation of heat-induced hydrolysis of sodium caseinate

  McGrath, B. A., Kinsella, M., Huppertz, T., McSweeney, P. L. H. & Kelly, A. L., 01 Feb 2016, In: International Dairy Journal. 53, p. 51-59 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sodium 100%
  • Casein 75%
  • Liquid Chromatography Mass Spectrometry 50%
  • Fluorescence Spectroscopy 50%
  • Trichloroacetic Acid 50%
  23 Citations (Scopus)

• Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

  Lal, C., McGrath, J., Subhash, H., Rani, S., Ritter, T. & Leahy, M., 2016, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Ho, A., Manns, F. & Soderberg, P. G. (eds.). SPIE, 96931U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9693).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Optical Coherence Tomography 100%
  • Stem Cell Therapy 100%
  • Diagnostic Imaging 20%
  • Refractive Surgery 20%
  • Wound Healing 20%
  2 Citations (Scopus)

• Structural Reorganization of CNC in Injection-Molded CNC/PBAT Materials under Thermal Annealing

  Mariano, M., El Kissi, N. & Dufresne, A., 2016, In: Langmuir.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Subclinical detection of diabetic cardiomyopathy with MicroRNAs: Challenges and perspectives

  León, L. E., Rani, S., Fernandez, M., Larico, M. & Calligaris, S. D., 2016, In: Journal of Diabetes Research. 2016, 6143129.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • microRNA 100%
  • Diabetic Cardiomyopathy 100%
  • Diseases 50%
  • Biological Marker 50%
  • Diastolic Dysfunction 50%
  36 Citations (Scopus)

• Synthesis and characterisation of mucoadhesive thiolated polyallylamine

  Duggan, S., Hughes, H., Owens, E., Duggan, E., Cummins, W. & O'Donovan, O., 29 Feb 2016, In: International Journal of Pharmaceutics. 499, 1-2, p. 368-375 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 2 Iminothiolane 100%
  • Thiol 100%
  • Mucin 100%
  • Rheology 100%
  • Pig 50%
  20 Citations (Scopus)

• Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

  Behl, G., O’Reilly, N. J., Fitzhenry, L., McLoughlin, P. & Iqbal, J., 01 Jul 2016, In: Pharmaceutical Research. 33, 7, p. 1638-1648 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dexamethasone Sodium Phosphate 100%
  • Chitosan Nanoparticle 100%
  • 2 Hydroxyethyl Methacrylate 100%
  • Nanoparticle 50%
  • Agents Acting on the Eye 33%
  75 Citations (Scopus)

• The National Exercise Referral Framework

  Harrison, M., Kehoe, B., Woods, C., McCaffrey, N., Murphy, M. H., Glynn, L., O'Riordan, J., O'Neill, B., Jennings, S. & Peppard, C., 2016, Health and Wellbeing Division, Health Service Executive. .

  Research output: Book/Report › Commissioned report

• Theoretical and experimental investigation of drug-polymer interaction and miscibility and its impact on drug supersaturation in aqueous medium

  Baghel, S., Cathcart, H. & O'Reilly, N. J., 01 Oct 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 107, p. 16-31 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Experimental Investigation 100%
  • Theoretical Investigation 100%
  • Aqueous Medium 100%
  • Amorphous Solid 100%
  • Supersaturation 100%
  75 Citations (Scopus)

• Thermal characterization of cellulose nanocrystals isolated from sisal fibers using acid hydrolysis

  Mariano, M., Cercená, R. & Soldi, V., 2016, In: Industrial Crops and Products.

  Research output: Contribution to journal › Article › peer-review
  111 Citations (Scopus)
• 2015

  Analysis of changes in phosphorylation of receptor tyrosine kinases: Antibody arrays

  Rani, S. & O’driscoll, L., 2015, In: Methods in Molecular Biology. 1233, p. 15-23 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor Tyrosine Kinase 100%
  • Ligand Binding Domain 20%
  • Ligand Binding 20%
  • Binding Protein 20%
  • Tyrosine Kinase 20%
  2 Citations (Scopus)

• Characterizing interacting regions between GluN subunits and the Src anchoring protein ND2 in the NMDAR complex

  Scanlon, D., Bah, A., Zhang, W., Krzeminski, M., Forman-Kay, J. D. & Salter, M. W., Jun 2015.

  Research output: Contribution to conference › Poster

• Facilitating cross-border rural micro-firm knowledge exchange: A community of practice perspective: A community of practice perspective

  Reinl, L., Owens, E., Kelliher, F. & Harrington, D., 01 Aug 2015, In: International Journal of Entrepreneurship and Innovation. 16, 3, p. 183-195 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Large Firm 100%
  • Specific Industry 100%
  • Communities-Of-Practice 100%
  • Economic Growth 33%
  • Knowledge Sharing 33%
  5 Citations (Scopus)

• Melt processing of cellulose nanocrystal reinforced polycarbonate from a masterbatch process

  Mariano, M., El Kissi, N. & Dufresne, A., 2015, In: European Polymer Journal.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity

  O'Brien, K., Lowry, M. C., Corcoran, C., Martinez, V. G., Daly, M., Rani, S., Gallagher, W. M., Radomski, M. W., MacLeod, R. A. F. & O'Driscoll, L., 2015, In: Oncotarget. 6, 32, p. 32774-32789 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hsp90 100%
  • Drug Sensitivity 100%
  • microRNA 100%
  • Triple Negative Breast Cancer 100%
  • MicroRNA 75%
  222 Citations (Scopus)

• Physical activity and its mechanistic effects on prostate cancer

  Wekesa, A., Harrison, M. & Watson, R. W., 14 Sep 2015, In: Prostate Cancer and Prostatic Diseases. 18, 3, p. 197-207 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Physical Activity 100%
  • Prostate Cancer 100%
  • Signal Transduction 30%
  • Malignant Neoplasm 16%
  • Cancer Growth 16%
  40 Citations (Scopus)

• Rationalized and complementary findings of silymarin (milk thistle) in Pakistani healthy volunteers

  Ashraf, M., Abid, F., Riffat, S., Bashir, S., Iqbal, J., Sarfraz, M., Afzal, A. & Zaheer, M., 2015, In: Acta Poloniae Pharmaceutica - Drug Research.

  Research output: Contribution to journal › Article › peer-review

  2 Citations (Scopus)

• Reciprocal Knowledge-Transfer Activities between SMEs and Academia

  Walsh, M., Storey, S., Dunne, B., Doyle, E., Gittins, H., Jones, R., Jones, S., Lane, E., Russell-O’Connor, J., Foley, A., Kent, T., Kennealy, M., Owens, E., Walmsley, J., Griffiths, G., McDonald, M., Bond, S., Breen, M., Griffin, R. & Harrington, D. & 1 others, Hearne, A., 2015

  Research output: Other contribution › peer-review

• Substrate evaluation of rhodococcus erythropolis SET1, a nitrile hydrolysing bacterium, demonstrating dual activity strongly dependent on nitrile sub-structure

  Coady, T. M., Coffey, L. V., O'Reilly, C. & Lennon, C. M., Feb 2015, In: European Journal of Organic Chemistry. 2015, 5, p. 1108-1116 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitrile 100%
  • Rhodococcus erythropolis 100%
  • Biotransformation 100%
  • Enzymatic Hydrolysis 100%
  • Carboxamide 20%
  16 Citations (Scopus)

• Synthesis of mucoadhesive thiolated gelatin using a two-step reaction process

  Duggan, S., O'Donovan, O., Owens, E., Cummins, W. & Hughes, H., Apr 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 91, p. 75-81 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Gelatin 100%
  • Thiol 25%
  • Carboxylate 12%
  • 2 Iminothiolane 12%
  • Ethylenediamine 12%
  30 Citations (Scopus)

• Ultra-thin flexible screen printed rechargeable polymer battery for wearable electronic applications

  Tehrani, Z., Korochkina, T., Govindarajan, S., Thomas, D. J., O'Mahony, J., Kettle, J., Claypole, T. C. & Gethin, D. T., 17 Aug 2015, In: Organic Electronics. 26, p. 386-394 9 p., 3229.

  Research output: Contribution to journal › Article › peer-review

  • Polystyrene 100%
  • Oxidation Reaction 100%
  • Electronic Circuit 100%
  • Anode 100%
  • Polyethylene Terephthalate 100%
  73 Citations (Scopus)
• 2014

  Biotransformations Using Nitrile Hydrolysing Enzymes For Stereoselective Organic Synthesis

  Coady, T., 2014, (Unpublished) 272 p.

  Research output: Types of Thesis › Doctoral Thesis

  File

  • Nitrile 100%
  • Hydroxynitrile 50%
  • Carboxamide 33%
  • Enzymatic Hydrolysis 33%
  • Enantioselectivity 16%
  8 Downloads (Pure)

• Cellulose nanocrystals and related nanocomposites: Review of some properties and challenges

  Mariano, M., El Kissi, N. & Dufresne, A., 2014, In: Journal of Polymer Science, Part B: Polymer Physics.

  Research output: Contribution to journal › Article › peer-review
  723 Citations (Scopus)

• Effect of a gelatin-based edible coating containing cellulose nanocrystals (CNC) on the quality and nutrient retention of fresh strawberries during storage

  Mariano, M., 2014, In: IOP Conf. Series: Materials Science and Engineering.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs

  Prieto, M. L., O'Sullivan, L., Tan, S. P., McLoughlin, P., Hughes, H., O'Donovan, O., Rea, M. C., Kent, R. M., Cassidy, J. P. & Lawlor, P. G., 26 Feb 2014, In: PLoS ONE. 9, 2, e88599.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pumilus 100%
  • Feeds 100%
  • Pig 100%
  • Probiotic 100%
  • Escherichia coli 40%
  36 Citations (Scopus)