Projects per year
Personal profile
Biography
Since finishing her PhD, Dr. Sweta Rani is actively involved in research, identifying biomarkers in disease and biomarkers for drug response. Her research outputs include 21 peer reviewed research articles and 4 review articles in high impact factor journals. She also published 7 book chapters and edited 2 books and her h-index is 20 with more than 3274 citations. She was awarded - Best Business Opportunity award, (Ignite Technology Transfer Office Eco-System); Early Career Award - Barcroft medal, (Royal Academy Of Medicine in Ireland and Biomedical Sciences); Irish Association for Cancer Research Award for Travel - Annual IACR conference; and Grant for travel- EMBL Advanced Training Centre Corporate Partnership Programme and EMBO Travel Grants, Postdoctoral education grant (Fannin grant), Irish Endocrine Society (summer student research grant) and won Illumina MiSeq at TrinSeq Competition.
As a research fellow in Trinity College Dublin, Ireland, she worked with diverse cancer type including HER2+ breast cancer, triple negative breast cancer, lung cancer and prostate cancer. Her work aimed to identify circulating biomarkers using microarray and molecular mechanism of acquired resistance to the drugs. Extensive molecular biology technique to alter the gene expression (transient, permanent knock-down and over-expression) was used, to understand the molecular mechanism of drug resistance.
Recently, her main focus is disease of the eye including corneal burn model, age-related macular degeneration (AMD) and dry eye.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes, Dublin City University
Award Date: 28 Mar 2009
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Investigating the Role of Glatiramer Acetate in Modulating Immune Effector Cells in Wet Age-Related Macular Degeneration.
Rani, S. (Principal Investigator) & Kuruppilakath Manikandan, S. (Team Member)
11/11/2019 → 04/03/2024
Project: National
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Investigating the Role of Glatiramer in Modulating Immune Effector Cells in a Model of Choroidal Neovascularization (CNV)
Rani, S. (Principal Investigator), Kuruppilakath Manikandan, S. (Team Member) & Kuruppilakath Manikandan, S. (Team Member)
01/04/2019 → 04/03/2024
Project: Industry
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Investigation of novel combination therapy for age-related macular degeneration on ARPE-19 cells
Dandamudi, M., Fitzhenry, L., Rani, S., McLoughlin, P., Coffey, L. V. & Behl, G., 19 Apr 2024, In: Frontiers in Drug Delivery. 4Research output: Contribution to journal › Article › peer-review
Open Access -
miRNAs as biomarkers of therapeutic response to HER2-targeted treatment in breast cancer: A systematic review
Vo, T. H., EL-Sherbieny Abdelaal, E., Jordan, E., O'Donovan, O., McNeela, E. A., Mehta, J. P. & Rani, S., 01 Mar 2024, In: Biochemistry and Biophysics Reports. 37, p. 101588 101588.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Analysis of miRNAs: Biomarkers for HER2-Targeted Breast Cancer Therapy
Vo, T. H., O’Donovan, O., McNeela, E., Mehta, J. P. & Rani, S., 31 Dec 2023, In: International Annals of Science.Research output: Contribution to journal › Article › peer-review
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Immune System, Inflammation and Autoantigens in Wet Age-Related Macular Degeneration: Pathological Significance and Therapeutic Importance
Manikandan, S. K., Logan, A., Cerrada-Gimenez, M., Fitzhenry, L., Coffey, L., Kaja, S. & Rani, S., Dec 2023, In: Life. 13, 12, 2236.Research output: Contribution to journal › Review article › peer-review
Open Access -
Preface
Rani, S., 2023, In: Methods in Molecular Biology. 2595, p. vResearch output: Contribution to journal › Editorial
Press/Media
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Findings from Waterford Advance Knowledge in Age-Related Macular Degeneration (Investigation of novel combination therapy for age-related macular degeneration on ARPE-19 cells)
Rani, S., Coffey, L. V., Fitzhenry, L., Behl, G., McLoughlin, P. & Dandamudi, M.
02/05/2024
1 item of Media coverage
Press/Media