A Nitrile-Metabolising Enzyme and a Process for Producing an Acid using Same

Lee V. Coffey; Catherine O'Reilly; Claire Lennon; Tracey Coady; Erica Owens; Panagiotis Manesiotis; Karen Tambling

A Nitrile-Metabolising Enzyme and a Process for Producing an Acid using Same

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

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Abstract

The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the ni- o trile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention exends to a process producing a carboxylic acid using said isolated polypeptide to
metabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.

Original language	English (Ireland)
Patent number	PCT/EP2012/063321
IPC	C12N 9/78 (2006.01) ,C12P 7/40 (2006.01)
Priority date	07/07/2011
Filing date	06/07/2012
Publication status	Published - 10 Jan 2013

Keywords

Nitrile
nucleotide sequence
Polypepide
NCIMB 41854

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title = "A Nitrile-Metabolising Enzyme and a Process for Producing an Acid using Same",

abstract = "The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the ni- o trile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention exends to a process producing a carboxylic acid using said isolated polypeptide tometabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.",

keywords = "Nitrile, nucleotide sequence, Polypepide, NCIMB 41854",

author = "Coffey, {Lee V.} and Catherine O'Reilly and Claire Lennon and Tracey Coady and Erica Owens and Panagiotis Manesiotis and Karen Tambling",

year = "2013",

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language = "English (Ireland)",

type = "Patent",

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T1 - A Nitrile-Metabolising Enzyme and a Process for Producing an Acid using Same

AU - Coffey, Lee V.

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Coady, Tracey

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

PY - 2013/1/10

Y1 - 2013/1/10

N2 - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the ni- o trile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention exends to a process producing a carboxylic acid using said isolated polypeptide tometabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.

AB - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the ni- o trile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention exends to a process producing a carboxylic acid using said isolated polypeptide tometabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.

KW - Nitrile

KW - nucleotide sequence

KW - Polypepide

KW - NCIMB 41854

M3 - Patent

M1 - PCT/EP2012/063321

Y2 - 2012/07/06

ER -

A Nitrile-Metabolising Enzyme and a Process for Producing an Acid using Same

Abstract

Keywords

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