A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24

Lee V. Coffey; Catherine O'Reilly; Claire Lennon; Tracey Coady; Erica Owens; Panagiotis Manesiotis; Karen Tambling

A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

Research output: Patent

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Abstract

The present invention relates to an isolated nitrile-metabolising Arthrobacter strain deposited under NCIMB 41855 and to amide or acid- producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrilemetabolising Arthrobacter strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is an isonitrile hydratase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing an amide or a carboxylic acid by metabolising nitrites such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy-phenylpropionitrile to form corresponding amides and carboxylic acids.

Original language	English (Ireland)
Patent number	1111641.5
Filing date	07/07/2011
Publication status	Published - 07 Jul 2011

Keywords

Amides
Acids
Nitrile-Metabolising Enzyme

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title = "A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24",

abstract = "The present invention relates to an isolated nitrile-metabolising Arthrobacter strain deposited under NCIMB 41855 and to amide or acid- producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrilemetabolising Arthrobacter strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is an isonitrile hydratase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing an amide or a carboxylic acid by metabolising nitrites such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy-phenylpropionitrile to form corresponding amides and carboxylic acids. ",

keywords = "Amides, Acids, Nitrile-Metabolising Enzyme",

author = "Coffey, {Lee V.} and Catherine O'Reilly and Claire Lennon and Tracey Coady and Erica Owens and Panagiotis Manesiotis and Karen Tambling",

year = "2011",

month = jul,

day = "7",

language = "English (Ireland)",

type = "Patent",

note = "1111641.5",

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TY - PAT

T1 - A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme

T2 - SS-24

AU - Coffey, Lee V.

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Coady, Tracey

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

PY - 2011/7/7

Y1 - 2011/7/7

N2 - The present invention relates to an isolated nitrile-metabolising Arthrobacter strain deposited under NCIMB 41855 and to amide or acid- producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrilemetabolising Arthrobacter strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is an isonitrile hydratase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing an amide or a carboxylic acid by metabolising nitrites such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy-phenylpropionitrile to form corresponding amides and carboxylic acids.

AB - The present invention relates to an isolated nitrile-metabolising Arthrobacter strain deposited under NCIMB 41855 and to amide or acid- producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrilemetabolising Arthrobacter strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is an isonitrile hydratase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing an amide or a carboxylic acid by metabolising nitrites such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxy-phenylpropionitrile to form corresponding amides and carboxylic acids.

KW - Amides

KW - Acids

KW - Nitrile-Metabolising Enzyme

M3 - Patent

M1 - 1111641.5

Y2 - 2011/07/07

ER -

A Process for Producing Amides and Acids using a Nitrile-Metabolising Enzyme: SS-24

Abstract

Keywords

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