A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes: SS-4

Lee V. Coffey; Catherine O'Reilly; Claire Lennon; Erica Owens; Panagiotis Manesiotis; Karen Tambling; Tracey Coady

A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes: SS-4

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor), Tracey Coady (Inventor)

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Abstract

The present invention relates to an isolated nitrile-metabolising Pantoea strain deposited under NCIMB 41853 and to amide or acid-producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile-metabolising Pantoea strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is a nitrilase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing a carboxylic acid by metabolising nitriles such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxyphenylpropionitrile to form corresponding carboxylic acids.

Original language	English (Ireland)
Patent number	1111637.3
Filing date	07/07/2011
Publication status	Published - 07 Jul 2011

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title = "A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes: SS-4",

abstract = "The present invention relates to an isolated nitrile-metabolising Pantoea strain deposited under NCIMB 41853 and to amide or acid-producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile-metabolising Pantoea strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is a nitrilase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing a carboxylic acid by metabolising nitriles such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxyphenylpropionitrile to form corresponding carboxylic acids. ",

author = "Coffey, {Lee V.} and Catherine O'Reilly and Claire Lennon and Erica Owens and Panagiotis Manesiotis and Karen Tambling and Tracey Coady",

year = "2011",

month = jul,

day = "7",

language = "English (Ireland)",

type = "Patent",

note = "1111637.3",

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TY - PAT

T1 - A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes

T2 - SS-4

AU - Coffey, Lee V.

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

AU - Coady, Tracey

PY - 2011/7/7

Y1 - 2011/7/7

N2 - The present invention relates to an isolated nitrile-metabolising Pantoea strain deposited under NCIMB 41853 and to amide or acid-producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile-metabolising Pantoea strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is a nitrilase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing a carboxylic acid by metabolising nitriles such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxyphenylpropionitrile to form corresponding carboxylic acids.

AB - The present invention relates to an isolated nitrile-metabolising Pantoea strain deposited under NCIMB 41853 and to amide or acid-producing mutants and variants thereof. Also provided is an isolated nucleotide sequence or polypeptide obtainable from the nitrile-metabolising Pantoea strain of the invention wherein the isolated nucleotide sequence or polypeptide encodes or is a nitrilase. The strain, isolated nucleotide sequence or polypeptide of the invention may be used in a process for producing a carboxylic acid by metabolising nitriles such as 3-hydroxyglutaronitrile, 3-hydroxy-butyronitrile and 3-hydroxyphenylpropionitrile to form corresponding carboxylic acids.

M3 - Patent

M1 - 1111637.3

Y2 - 2011/07/07

ER -

A Process for Producing Amides and Acids using Nitrile-Metabolising Enzymes: SS-4

Abstract

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