TY - JOUR
T1 - A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score)
T2 - a development and validation study in three international cohorts
AU - NIHR Global Health Research Unit on Global Surgery
AU - STARSurg Collaborative
AU - Bravo, Laura
AU - Simões, Joana FF
AU - Cardoso, Victor R.
AU - Adisa, Adewale
AU - Aguilera, Maria L.
AU - Arnaud, Alexis
AU - Biccard, Bruce
AU - Calvache, Jose
AU - Chernbumroong, Saisakul
AU - Elhadi, Muhammed
AU - Ghosh, Dhruv
AU - Gujjuri, Rohan
AU - Harrison, Ewen
AU - Ho, Michael WS
AU - Kasivisvanathan, Veerappan
AU - Kouli, Omar
AU - Lederhuber, Hans
AU - Li, Elizabeth
AU - Löffler, Markus W.
AU - Isik, Arda
AU - Marcus, Hani
AU - Martin, Janet
AU - McLean, Kenneth A.
AU - Minaya-Bravo, Ana
AU - Modolo, María Marta
AU - Nepogodiev, Dmitri
AU - Pellino, Gianluca
AU - Picciochi, Maria
AU - Pockney, Peter
AU - van Ramshorst, Gabriëlle
AU - Riad, Aya
AU - Sayyed, Raza
AU - Sund, Malin
AU - Gkoutos, Georgios
AU - Bhangu, Aneel A.
AU - Glasbey, James C.
AU - Cardoso, V.
AU - Glasbey, J.
AU - Simoes, J. F.F.
AU - Kadir, B.
AU - Omar, O.
AU - Revell, E.
AU - Bahrami-Hessari, M.
AU - Ahmed, Waheed Ul Rahman
AU - Argus, Leah
AU - Ball, Alasdair
AU - Bhangu, Aneel
AU - Bywater, Edward P.
AU - Blanco-Colino, Ruth
AU - O'Sullivan, H.
N1 - Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
PY - 2024/7
Y1 - 2024/7
N2 - Background: Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support resource allocation and prioritisation during pandemic recovery. Methods: Data from an international, prospective cohort study were used to develop a novel prognostic risk model for pulmonary complications after elective surgery in adult patients (aged ≥18 years) across all operation and disease types. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery, which was a composite of pneumonia, acute respiratory distress syndrome, and unexpected mechanical ventilation. Model development with candidate predictor variables was done in the GlobalSurg-CovidSurg Week dataset (global; October, 2020). Two structured machine learning techniques were explored (XGBoost and the least absolute shrinkage and selection operator [LASSO]), and the model with the best performance (GSU-Pulmonary Score) underwent internal validation using bootstrap resampling. The discrimination and calibration of the score were externally validated in two further prospective cohorts: CovidSurg-Cancer (worldwide; February to August, 2020, during the COVID-19 pandemic) and RECON (UK and Australasia; January to October, 2019, before the COVID-19 pandemic). The model was deployed as an online web application. The GlobalSurg-CovidSurg Week and CovidSurg-Cancer studies were registered with ClinicalTrials.gov, NCT04509986 and NCT04384926. Findings: Prognostic models were developed from 13 candidate predictor variables in data from 86 231 patients (1158 hospitals in 114 countries). External validation included 30 492 patients from CovidSurg-Cancer (726 hospitals in 75 countries) and 6789 from RECON (150 hospitals in three countries). The overall rates of pulmonary complications were 2·0% in derivation data, and 3·9% (CovidSurg-Cancer) and 4·7% (RECON) in the validation datasets. Penalised regression using LASSO had similar discrimination to XGBoost (area under the receiver operating curve [AUROC] 0·786, 95% CI 0·774–0·798 vs 0·785, 0·772–0·797), was more explainable, and required fewer covariables. The final GSU-Pulmonary Score included ten predictor variables and showed good discrimination and calibration upon internal validation (AUROC 0·773, 95% CI 0·751–0·795; Brier score 0·020, calibration in the large [CITL] 0·034, slope 0·954). The model performance was acceptable on external validation in CovidSurg-Cancer (AUROC 0·746, 95% CI 0·733–0·760; Brier score 0·036, CITL 0·109, slope 1·056), but with some miscalibration in RECON data (AUROC 0·716, 95% CI 0·689–0·744; Brier score 0·045, CITL 1·040, slope 1·009). Interpretation: This novel prognostic risk score uses simple predictor variables available at the time of a decision for elective surgery that can accurately stratify patients’ risk of postoperative pulmonary complications, including during SARS-CoV-2 outbreaks. It could inform surgical consent, resource allocation, and hospital-level prioritisation as elective surgery is upscaled to address global backlogs. Funding: National Institute for Health Research.
AB - Background: Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support resource allocation and prioritisation during pandemic recovery. Methods: Data from an international, prospective cohort study were used to develop a novel prognostic risk model for pulmonary complications after elective surgery in adult patients (aged ≥18 years) across all operation and disease types. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery, which was a composite of pneumonia, acute respiratory distress syndrome, and unexpected mechanical ventilation. Model development with candidate predictor variables was done in the GlobalSurg-CovidSurg Week dataset (global; October, 2020). Two structured machine learning techniques were explored (XGBoost and the least absolute shrinkage and selection operator [LASSO]), and the model with the best performance (GSU-Pulmonary Score) underwent internal validation using bootstrap resampling. The discrimination and calibration of the score were externally validated in two further prospective cohorts: CovidSurg-Cancer (worldwide; February to August, 2020, during the COVID-19 pandemic) and RECON (UK and Australasia; January to October, 2019, before the COVID-19 pandemic). The model was deployed as an online web application. The GlobalSurg-CovidSurg Week and CovidSurg-Cancer studies were registered with ClinicalTrials.gov, NCT04509986 and NCT04384926. Findings: Prognostic models were developed from 13 candidate predictor variables in data from 86 231 patients (1158 hospitals in 114 countries). External validation included 30 492 patients from CovidSurg-Cancer (726 hospitals in 75 countries) and 6789 from RECON (150 hospitals in three countries). The overall rates of pulmonary complications were 2·0% in derivation data, and 3·9% (CovidSurg-Cancer) and 4·7% (RECON) in the validation datasets. Penalised regression using LASSO had similar discrimination to XGBoost (area under the receiver operating curve [AUROC] 0·786, 95% CI 0·774–0·798 vs 0·785, 0·772–0·797), was more explainable, and required fewer covariables. The final GSU-Pulmonary Score included ten predictor variables and showed good discrimination and calibration upon internal validation (AUROC 0·773, 95% CI 0·751–0·795; Brier score 0·020, calibration in the large [CITL] 0·034, slope 0·954). The model performance was acceptable on external validation in CovidSurg-Cancer (AUROC 0·746, 95% CI 0·733–0·760; Brier score 0·036, CITL 0·109, slope 1·056), but with some miscalibration in RECON data (AUROC 0·716, 95% CI 0·689–0·744; Brier score 0·045, CITL 1·040, slope 1·009). Interpretation: This novel prognostic risk score uses simple predictor variables available at the time of a decision for elective surgery that can accurately stratify patients’ risk of postoperative pulmonary complications, including during SARS-CoV-2 outbreaks. It could inform surgical consent, resource allocation, and hospital-level prioritisation as elective surgery is upscaled to address global backlogs. Funding: National Institute for Health Research.
KW - Humans
KW - Elective Surgical Procedures/adverse effects
KW - Postoperative Complications/epidemiology
KW - Female
KW - Prognosis
KW - Middle Aged
KW - Male
KW - Prospective Studies
KW - Aged
KW - COVID-19/epidemiology
KW - Risk Assessment/methods
KW - Adult
KW - Machine Learning
KW - Risk Factors
KW - Lung Diseases/etiology
KW - Cohort Studies
UR - http://www.scopus.com/inward/record.url?scp=85196614725&partnerID=8YFLogxK
U2 - 10.1016/S2589-7500(24)00065-7
DO - 10.1016/S2589-7500(24)00065-7
M3 - Article
C2 - 38906616
AN - SCOPUS:85196614725
SN - 2589-7500
VL - 6
SP - e507-e519
JO - The Lancet Digital Health
JF - The Lancet Digital Health
IS - 7
ER -