Clinical trials investigating the macular carotenoids

Sarah Sabour-Pickett, John M. Nolan, Stephen Beatty

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


The anatomical (central retinal), biochemical (antioxidant), and optical (short-wavelength filtering) properties of macular pigment (MP) have generated interest in the biologically plausible rationale that MP may not only confer protection against age-related macular degeneration (AMD) but also optimize vision. The testing of this hypothesis has been a subject of growing interest over the past decade. This chapter reviews the evidence from the clinical trials that have investigated the role of macular carotenoid supplementation on macular pigment optical density (MPOD), on visual performance, and on the risk of disease progression in subjects afflicted with AMD. In addition, the more recent studies investigating the impact of supplementation with the macular carotenoids on visual performance in normal subjects (without disease) will be discussed.

Original languageEnglish
Title of host publicationCarotenoids and Retinal Disease
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781466502055
ISBN (Print)9781466502048
Publication statusPublished - 01 Jan 2013


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