Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Lee V. Coffey; Catherine O'Reilly; Claire Lennon; Tracey Coady; Erica Owens; Panagiotis Manesiotis; Karen Tambling

Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Lee V. Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

Research output: Patent

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Abstract

The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

Original language	English (Ireland)
Patent number	PCT/EP2012/063323
IPC	C12N 9/78 (2006.0 1),C12P 13/00 (2006.0 1),CUP 13/02 (2006.01)
Priority date	07/07/2011
Filing date	06/07/2012
Publication status	Published - 10 Jan 2013

Keywords

Isolated nucleotide sequence
Polypeptide
Arthrobacter
NCIMB 41855

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WO_2013_004835_A1

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title = "Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same",

abstract = "The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.",

keywords = "Isolated nucleotide sequence, Polypeptide, Arthrobacter, NCIMB 41855",

author = "Coffey, {Lee V.} and Catherine O'Reilly and Claire Lennon and Tracey Coady and Erica Owens and Panagiotis Manesiotis and Karen Tambling",

year = "2013",

month = jan,

day = "10",

language = "English (Ireland)",

type = "Patent",

note = "PCT/EP2012/063323; C12N 9/78 (2006.0 1),C12P 13/00 (2006.0 1),CUP 13/02 (2006.01)",

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TY - PAT

T1 - Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

AU - Coffey, Lee V.

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Coady, Tracey

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

PY - 2013/1/10

Y1 - 2013/1/10

N2 - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

AB - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

KW - Isolated nucleotide sequence

KW - Polypeptide

KW - Arthrobacter

KW - NCIMB 41855

M3 - Patent

M1 - PCT/EP2012/063323

Y2 - 2012/07/06

ER -

Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Abstract

Keywords

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