Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Lee V. Coffey; Catherine O'Reilly; Claire Lennon; Tracey Coady; Erica Owens; Panagiotis Manesiotis; Karen Tambling

Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Lee V. Coffey (Inventor)
, Catherine O'Reilly (Inventor)
, Claire Lennon (Inventor)
, Tracey Coady (Inventor)
, Erica Owens (Inventor)
, Panagiotis Manesiotis (Inventor)
, Karen Tambling (Inventor)

Research output: Patent

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Abstract

The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

Original language	English (Ireland)
Patent number	PCT/EP2012/063323
IPC	C12N 9/78 (2006.0 1),C12P 13/00 (2006.0 1),CUP 13/02 (2006.01)
Priority date	07/07/2011
Filing date	06/07/2012
Publication status	Published - 10 Jan 2013

Keywords

Isolated nucleotide sequence
Polypeptide
Arthrobacter
NCIMB 41855

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WO_2013_004835_A1

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title = "Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same",

abstract = "The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.",

keywords = "Isolated nucleotide sequence, Polypeptide, Arthrobacter, NCIMB 41855",

author = "Coffey, \{Lee V.\} and Catherine O'Reilly and Claire Lennon and Tracey Coady and Erica Owens and Panagiotis Manesiotis and Karen Tambling",

year = "2013",

month = jan,

day = "10",

language = "English (Ireland)",

type = "Patent",

note = "PCT/EP2012/063323; C12N 9/78 (2006.0 1),C12P 13/00 (2006.0 1),CUP 13/02 (2006.01)",

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TY - PAT

T1 - Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

AU - Coffey, Lee V.

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Coady, Tracey

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

PY - 2013/1/10

Y1 - 2013/1/10

N2 - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

AB - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the o isonitrile-metabolising Arthrobacter strain deposited under NCIMB 41855. Said isolated polypeptide acts as an isonitrile hydratase and the invention extends to a process for producing an N-substituted formamide or carboxylic acid using said isolated polypeptide to metabolise isonitriles or nitriles to form corresponding amides or carboxylic acids.

KW - Isolated nucleotide sequence

KW - Polypeptide

KW - Arthrobacter

KW - NCIMB 41855

M3 - Patent

M1 - PCT/EP2012/063323

Y2 - 2012/07/06

ER -

Isonitrile and Nitrile-Metabolising Enzymes and a Process for Producing Amides and Acids using same

Abstract

Keywords

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