TY - JOUR
T1 - Macular pigment and ocular biometry
AU - Neelam, Kumari
AU - Nolan, John
AU - Loane, Edward
AU - Stack, Jim
AU - O'Donovan, Orla
AU - Au Eong, Kah Guan
AU - Beatty, Stephen
N1 - Funding Information:
This study was funded by Research and Development Department, Kemin Foods, Europe. The authors acknowledge Ms. Leigh-Ann Maddock for the invaluable help in the data collection.
PY - 2006/6
Y1 - 2006/6
N2 - This study is designed to investigate the relationship between macular pigment optical density (MPOD) and ocular biometric parameters. The following details were recorded for 180 healthy subjects: demographic profile; best-corrected visual acuity; refractive status; ocular biometric parameters [axial length (AL), anterior chamber depth (ACD), lens thickness (LT) and vitreous chamber depth (VCD)]; ocular dominance; MPOD; serum lutein (L) and zeaxanthin (Z). The mean MPOD (±SD) was 0.307 (0.155) and 0.305 (0.149) in the right and left eyes, respectively. No demonstrable relationship was observed between MPOD and AL, ACD or VCD [AL: r = 0.091, p = 0.225; ACD: r = 0.091, p = 0.227; VCD: r = 0.146, p = 0.051]. There was a significant and inverse relationship between LT and MPOD (r = -0.204; p = 0.008), which was attenuated to non-significance after correction for age and height (r = -0.058; p = 0.466). This study fails to identify an association between MPOD and ocular biometric parameters. This is an important negative finding, which allows investigators to study MP, and its relationship with potentially important variables, without the need to correct for ocular biometric parameters.
AB - This study is designed to investigate the relationship between macular pigment optical density (MPOD) and ocular biometric parameters. The following details were recorded for 180 healthy subjects: demographic profile; best-corrected visual acuity; refractive status; ocular biometric parameters [axial length (AL), anterior chamber depth (ACD), lens thickness (LT) and vitreous chamber depth (VCD)]; ocular dominance; MPOD; serum lutein (L) and zeaxanthin (Z). The mean MPOD (±SD) was 0.307 (0.155) and 0.305 (0.149) in the right and left eyes, respectively. No demonstrable relationship was observed between MPOD and AL, ACD or VCD [AL: r = 0.091, p = 0.225; ACD: r = 0.091, p = 0.227; VCD: r = 0.146, p = 0.051]. There was a significant and inverse relationship between LT and MPOD (r = -0.204; p = 0.008), which was attenuated to non-significance after correction for age and height (r = -0.058; p = 0.466). This study fails to identify an association between MPOD and ocular biometric parameters. This is an important negative finding, which allows investigators to study MP, and its relationship with potentially important variables, without the need to correct for ocular biometric parameters.
KW - Anterior chamber depth
KW - Axial length
KW - Lens thickness
KW - Macular pigment
KW - Vitreous chamber depth
UR - http://www.scopus.com/inward/record.url?scp=33644827873&partnerID=8YFLogxK
U2 - 10.1016/j.visres.2005.12.012
DO - 10.1016/j.visres.2005.12.012
M3 - Article
C2 - 16472837
AN - SCOPUS:33644827873
SN - 0042-6989
VL - 46
SP - 2149
EP - 2156
JO - Vision Research
JF - Vision Research
IS - 13
ER -