@article{acc5eab3e1074d5d8e70827a597f00fd,
title = "Macular pigment and visual function in patients with glaucoma: The san diego macular pigment study",
abstract = " PURPOSE. Although recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation. M ETHODS . This cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression models accounting for potential confounding factors. R ESULTS . Glaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P < 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable model, diagnosis of glaucoma was not associated with MP volume (R 2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) models. C ONCLUSIONS . These results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients. ",
keywords = "Carotenoids, Glaucoma, Macular pigment, Visual function",
author = "Daga, {F{\'a}bio B.} and Ogata, {Nara G.} and Medeiros, {Felipe A.} and Rachel Moran and Jeffrey Morris and Zangwill, {Linda M.} and Weinreb, {Robert N.} and Nolan, {John M.}",
note = "Funding Information: Supported by University of California San Diego Vision Research Core Grant EY0222589; National Institutes of Health (NIH) Grants P30EY022589, EY11008, EY019869, EY021818, EY27510. An unrestricted grant was also received from Research to Prevent Blindness, New York, New York. The macular pigment work for this project was supported via an unrestricted research grant from IOSA (Industrial Org{\'a}nica S.A., Monterrey, Nuevo Le{\'o}n, Mexico), MacuHealth LLC (Birmingham, MI, USA), and Heidelberg Engineering GmbH (Max-Jarecki-Stra{\ss}e 8, 69115 Heidelberg, Deutschland). Funding Information: Supported by University of California San Diego Vision Research Core Grant EY0222589; National Institutes of Health (NIH) Grants P30EY022589, EY11008, EY019869, EY021818, EY27510. An unrestricted grant was also received from Research to Prevent Blindness, New York, New York. The macular pigment work for this project was supported via an unrestricted research grant from IOSA (Industrial Org{\'a}nica S.A., Monterrey, Nuevo Le{\'o}n, Mexico), MacuHealth LLC (Birmingham, MI, USA), and Heidelberg Engineering GmbH (Max-Jarecki-Stra{\ss}e 8, 69115 Heidelberg, Deutschland). Disclosure: F.B. Daga, None; N.G. Ogata, None; F.A. Medeiros, Alcon Laboratories (C, F, R), Bausch & Lomb (F), Carl Zeiss Meditec (C, F, R), Heidelberg Engineering (F), Merck (F), Allergan (C, F), Sensimed (C), Topcon (C), Reichert (C, R), National Eye Institute (C), nGoggle (I); R. Moran, None; J. Morris, None; L.M. Zangwill, National Eye Institute (F), Carl Zeiss Meditec (F), Heidelberg Engineering (F), Optovue (F), Topcon Medical Systems (F); R.N. Weinreb, Alcon Laboratories (C), Allergan (C), Bausch & Lomb (C), Carl Zeiss Meditec (F), Eyenovia (C), Genentech (F), Heidelberg Engineering (F), National Eye Institute (F), Novartis (C), Optos (F), Optovue (F), Tomey (F), Topcon (F); J.M. Nolan, Nutrasight (C). Publisher Copyright: {\textcopyright} 2018 The Authors.",
year = "2018",
month = sep,
doi = "10.1167/iovs.18-24170",
language = "English",
volume = "59",
pages = "4471--4476",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "11",
}