microRNAs in parasite-induced liver fibrosis: from mechanisms to diagnostics and therapeutics

Mengqi Liu, William C. Cho, Robin J. Flynn, Xiaoliang Jin, Houhui Song, Yadong Zheng

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic parasite infections in the liver pose a global threat to human and animal health, often occurring with liver fibrosis that leads to cirrhosis, liver failure, and even cancer. Hepatic fibrogenesis is a complex yet reversible process of tissue repair and is associated with various factors, including immune cells, microenvironment, gut microbiome, and interactions of the different liver cells. As a profibrogenic or antifibrogenic driver, microRNAs (miRNAs) are closely involved in parasite-induced hepatic fibrosis. This article updates the current understanding of the roles of miRNAs in hepatic fibrogenesis by parasite infections and discusses the strategies using miRNAs as candidates for diagnostics and therapeutics.

Original languageEnglish
Pages (from-to)859-872
Number of pages14
JournalTrends in Parasitology
Volume39
Issue number10
DOIs
Publication statusPublished - 13 Sep 2023

Keywords

  • hepatic stellate cell
  • liver
  • liver fibrosis
  • miRNA
  • parasite
  • MicroRNAs/genetics
  • Animals
  • Hepatocytes
  • Hepatic Stellate Cells
  • Humans
  • Liver Cirrhosis/diagnosis
  • Parasites

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