TY - JOUR
T1 - microRNAs in parasite-induced liver fibrosis
T2 - from mechanisms to diagnostics and therapeutics
AU - Liu, Mengqi
AU - Cho, William C.
AU - Flynn, Robin J.
AU - Jin, Xiaoliang
AU - Song, Houhui
AU - Zheng, Yadong
N1 - Funding Information:
This study was supported by grants from the Scientific Research and Development Talent Fund of Zhejiang Agriculture and Forestry University ( 2021LFR038 ), the Key R&D Program of Zhejiang Province ( 2019C02052 ), and the National Natural Science Foundation of China ( U1703104 ). The authors are indebted to Mr Guanghui Zheng for helping with figure preparation.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9/13
Y1 - 2023/9/13
N2 - Chronic parasite infections in the liver pose a global threat to human and animal health, often occurring with liver fibrosis that leads to cirrhosis, liver failure, and even cancer. Hepatic fibrogenesis is a complex yet reversible process of tissue repair and is associated with various factors, including immune cells, microenvironment, gut microbiome, and interactions of the different liver cells. As a profibrogenic or antifibrogenic driver, microRNAs (miRNAs) are closely involved in parasite-induced hepatic fibrosis. This article updates the current understanding of the roles of miRNAs in hepatic fibrogenesis by parasite infections and discusses the strategies using miRNAs as candidates for diagnostics and therapeutics.
AB - Chronic parasite infections in the liver pose a global threat to human and animal health, often occurring with liver fibrosis that leads to cirrhosis, liver failure, and even cancer. Hepatic fibrogenesis is a complex yet reversible process of tissue repair and is associated with various factors, including immune cells, microenvironment, gut microbiome, and interactions of the different liver cells. As a profibrogenic or antifibrogenic driver, microRNAs (miRNAs) are closely involved in parasite-induced hepatic fibrosis. This article updates the current understanding of the roles of miRNAs in hepatic fibrogenesis by parasite infections and discusses the strategies using miRNAs as candidates for diagnostics and therapeutics.
KW - hepatic stellate cell
KW - liver
KW - liver fibrosis
KW - miRNA
KW - parasite
KW - MicroRNAs/genetics
KW - Animals
KW - Hepatocytes
KW - Hepatic Stellate Cells
KW - Humans
KW - Liver Cirrhosis/diagnosis
KW - Parasites
UR - http://www.scopus.com/inward/record.url?scp=85166624585&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/abs/pii/S1471492223001678#:~:text=Chronic%20parasite%20infections%20in%20liver,inhibit%20overaction%20of%20hepatic%20fibrogenesis.
U2 - 10.1016/j.pt.2023.07.001
DO - 10.1016/j.pt.2023.07.001
M3 - Article
C2 - 37516634
AN - SCOPUS:85166624585
SN - 1471-4922
VL - 39
SP - 859
EP - 872
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 10
ER -