Pulmonary Drug Delivery Systems: Material and Technological Advances

Nasser Al-Hajj, Niall O'Reilly, H Cathcart

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Nanoparticles have been developed to overcome the limitation of free therapeutics and enable targeting of specific sites in a controlled manner; they have been proven to be effective as drug carriers and diagnostic tools. Pulmonary drug delivery is greatly preferred in the treatment of lung diseases and has its advantages over other drug delivery routes in the treatment of systemic diseases as well. However, delivering nanoparticles to the lung is hindered by their physical instability and poor lung deposition efficiency due to particle-particle interaction and low inertia, respectively. Developing inhalable nanoparticles as part of an inhalable solid state dry powder combines the advantages of pulmonary and nanoparticle drug delivery systems and offers unique advantages. Several particle engineering techniques have been utilized to combine nanoparticles within a form of micron-scale dry powder carrier with improved handling and aerosolization properties and the ability to release the nanoparticles upon deposition in the lungs. This chapter will describe the different classes of nanoparticles and the different inhalable nano-in-micro dry particle frameworks. The different particle engineering techniques used for developing these frameworks will also be discussed.

Original languageEnglish
Title of host publicationPulmonary Drug Delivery Systems
Subtitle of host publicationMaterial and Technological Advances
EditorsPiyush Pradeep Mehta, Vividha Dhapte-Pawar
PublisherSpringer
Chapter4
Pages91-130
Number of pages39
ISBN (Electronic)9789819919239
ISBN (Print)9789819919222
DOIs
Publication statusPublished - 01 Jan 2023

Keywords

  • Dry powder inhaler
  • Microparticles
  • Nano-in-microparticle engineering
  • Nanoparticles
  • Pulmonary drug delivery

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