Recent advances in the methodology, optimisation and application of MEEKC

Richie Ryan, Sheila Donegan, Joe Power, Eamon McEvoy, Kevin Altria

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)


MEEKC is an electrodriven separation technique. Oil-in-water microemulsions (MEs) and to a lesser extent water-in-oil MEs have been used in MEEKC as BGEs to achieve separation of a diverse range of solutes. The more common (oil-in-water) MEs are composed of nanometre-sized droplets of oil suspended in an aqueous buffer. Interfacial tension between the oil and aqueous phase is reduced close to zero by the presence of a surfactant and a co-surfactant. MEEKC is capable of providing fast and efficient separations for a wide range of acidic, basic and neutral, water-soluble and -insoluble compounds. This review details the advances in MEEKC-based separations from the period 2006 to 2008. Areas covered include online sample concentration, chiral separation, suppressed electroosmosis MEEKC, MEEKC-MS, and the use of MEEKC in predicting migration behaviour and solute characteristics. A fundamental introduction to MEEKC, along with the presentation and discussion of recent applications is also included.

Original languageEnglish
Pages (from-to)65-82
Number of pages18
Issue number1
Publication statusPublished - 2009


  • Applications
  • Chiral separation
  • Electrokinetic chromatography
  • Microemulsions


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