TY - JOUR
T1 - Relationship between macular pigment and visual function in subjects with early age-related macular degeneration
AU - Akuffo, Kwadwo Owusu
AU - Nolan, John M.
AU - Peto, Tunde
AU - Stack, Jim
AU - Leung, Irene
AU - Corcoran, Laura
AU - Beatty, Stephen
N1 - Funding Information:
This study was funded by the European Research Council (ERC); reference number: 281096. KOA, LC and JMN were funded by the European Research Council. JMN was also funded by the Howard Foundation, Cambridge, UK. TP and IL were funded by the NIHR BMRC at Moorfields Eye Hospital NHS Foundation Trust and UCL IoO, London, UK.
PY - 2017/2
Y1 - 2017/2
N2 - Purpose To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD). Methods 121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). MP was measured using customised heterochromatic flicker photometry. Results Letter CS, mesopic and photopic CS, photopic GD and mean reading speed were each significantly (p<0.05) associated with MP across a range of retinal eccentricities, and these statistically significant relationships persisted after controlling for age, sex and cataract grade. BCVA, NEI VFQ-25 score, PRT and mesopic GD were unrelated to MP after controlling for age, sex and cataract grade (p>0.05, for all). Conclusions MP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. Trial registration number ISRCTN13894787.
AB - Purpose To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD). Methods 121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). MP was measured using customised heterochromatic flicker photometry. Results Letter CS, mesopic and photopic CS, photopic GD and mean reading speed were each significantly (p<0.05) associated with MP across a range of retinal eccentricities, and these statistically significant relationships persisted after controlling for age, sex and cataract grade. BCVA, NEI VFQ-25 score, PRT and mesopic GD were unrelated to MP after controlling for age, sex and cataract grade (p>0.05, for all). Conclusions MP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. Trial registration number ISRCTN13894787.
KW - Degeneration
KW - Macula
KW - Psychophysics
KW - Retina
KW - Vision
UR - http://www.scopus.com/inward/record.url?scp=84982136480&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2016-308418
DO - 10.1136/bjophthalmol-2016-308418
M3 - Article
C2 - 27091854
AN - SCOPUS:84982136480
SN - 0007-1161
VL - 101
SP - 190
EP - 197
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 2
ER -