Subclinical detection of diabetic cardiomyopathy with MicroRNAs: Challenges and perspectives

L.E. León, S. Rani, M. Fernandez, M. Larico, S.D. Calligaris

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.

Original languageEnglish
Article number6143129
JournalJournal of Diabetes Research
Publication statusPublished - 2016


Dive into the research topics of 'Subclinical detection of diabetic cardiomyopathy with MicroRNAs: Challenges and perspectives'. Together they form a unique fingerprint.

Cite this