@article{d660787ce4a64df8802c1059a921ab94,
title = "The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample",
abstract = "Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD). Material and methods: Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware; Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence of AMD. Results: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs, 288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and age, the relationship between grading-confirmed AMD and plasma L was positive and significant (p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 µmol) and Group 4 (mean = 0.2040 ± 0.121 µmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 µmol/L) and Group 3 (mean = 0.3176 ± 0.0.235 µmol/L). Supplement use was reported by 41.7% and 17.1% of participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4, respectively. Conclusion: A belief that one suffers from AMD, whether justified or not, is associated with supplement use and with higher plasma concentrations of L.",
keywords = "age-related macular degeneration, awareness, Lutein, supplements, zeaxanthin",
author = "Rachel Moran and Stephen Beatty and Jim Stack and O{\textquoteright}Halloran, {Aisling M.} and Joanne Feeney and Akuffo, {Kwadwo O.} and Tunde Peto and Kenny, {Rose Anne} and Nolan, {John M.}",
note = "Funding Information: We would like thank the TILDA participants, research team, field researchers and research nurses who conducted tests in TILDA. This work was supported by Bayer, Ireland and Waterford Institute of Technology Presidential Scholarship. TILDA is funded by An Roinn Sl?inte (Irish Department of Health), The Atlantic Philanthropies, and Irish Life plc. The funders had no role in the study design or in the collection, analysis and interpretation of the data or in the writing of the report or in the decision to submit the article for publication. JMN and KOA were funded by the European Research Council (ERC). JF and AOH were funded by the Centre for Ageing Development and Research in Ireland (CARDI). TP was funded by the NIHR BMRC at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. Funding Information: This work was supported by Bayer, Ireland and Waterford Institute of Technology Presidential Scholarship. TILDA is funded by An Roinn Sl{\'a}inte (Irish Department of Health), The Atlantic Philanthropies, and Irish Life plc. The funders had no role in the study design or in the collection, analysis and interpretation of the data or in the writing of the report or in the decision to submit the article for publication. JMN and KOA were funded by the European Research Council (ERC). JF and AOH were funded by the Centre for Ageing Development and Research in Ireland (CARDI). TP was funded by the NIHR BMRC at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. Publisher Copyright: {\textcopyright} 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2018",
month = mar,
day = "4",
doi = "10.1080/02713683.2017.1403633",
language = "English",
volume = "43",
pages = "383--390",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Taylor and Francis",
number = "3",
}